The Transformation of Sero-fibrinous into Purulent Pleurisy
نویسنده
چکیده
The preceding study has shown that turpentine (one cubic centimeter) injected into the pleural cavity of the dog causes rapid exudation of a large quantity of coagulable fluid. Fibrin containing a considerable proportion of the leucocytes which migrate from the blood vessels as a result of the chemiotactic action of the irritant is deposited upon pleural surfaces and the serous fluid about this fibrin contains only a small number of leucocytes. In the fluid is an antienzyme which holds in check the enzyme contained in the polynuclear leucocytes, so that resolution of fibrin proceeds slowly, and at no time does the exudate assume the appearance of pus. The pleural surfaces undergo no permanent alteration, and at the end of about two weeks, the pleural cavity has in most instances become normal, save for a few organized adhesions. When the same quantity of the inflammatory irritant is injected into the subcutaneous tissue, it is not diluted by a large quantity of fluid. A considerable volume of fluid, perhaps with the aid of the negative pressure within the thorax, readily collects in the relatively spacious pleural cavity, whereas accumulation of fluid in the subcutaneous tissue is checked by the increase of tension which occurs when the tissue is infiltrated with fluid and leucocytes. Examination of this pus has shown 1 that leucoprotease of the poly-nuclear leucocytes so far exceeds anti-body contained in the serum of the pus that the entire exudate undergoes autolysis when placed under suitable conditions. If the essential difference between the suppurative inflammation of the subcutaneous tissue with solution of tissue, on the one hand, and the sero-fibrinous pleurisy, with which for a considerable time fibrin remains undissolved, on the other hand, is the relative
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 9 شماره
صفحات -
تاریخ انتشار 2003